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Cassava Sciences (SAVA) Is Up 200% In 6 Days, What’s The Buzz?

Monday December 30 th 2019

(RTTNews) – Shares of Cassava Sciences Inc. (SAVA), which closed at a 52-week high of $5.21 on Friday (Dec.27), are up a whopping 210% over the last 6 trading days.

Cassava Sciences is a clinical-stage biotechnology company developing PTI-125, a novel drug treatment for Alzheimer’s disease, and PTI-125Dx, an investigational diagnostic to detect Alzheimer’s with a simple blood test.

The lead drug candidate PTI-125 has a novel mechanism of action designed to restore the normal shape/function of Filamin A (FLNA), a scaffolding protein that misfolds in the brain with Alzheimer’s.

In a phase IIa study funded by the National Institutes of Health, the results of which were announced early in September of this year, treatment with PTI-125 for 28 days significantly reduced key biomarkers of neuroinflammation and neurodegeneration in all 13 patients, according to the Company.

Based on the phase IIa results that demonstrated a 100% response rate, Cassava Sciences initiated a phase IIb study of PTI-125, in Alzheimer’s patients the same month (September 2019). This study, supported by a research grant award from the National Institutes of Health, is designed to enroll about 60 patients with mild-to-moderate Alzheimer’s disease who will be dosed with PTI-125 100 mg, 50 mg, or matching placebo, twice daily for 28 continuous days.

The primary endpoint is an improvement in biomarkers of Alzheimer’s disease from baseline to Day 28. The results of the phase IIb study of PTI-125 in Alzheimer’s are expected in the fourth quarter of 2020.

The investigational diagnostic PTI-125Dx in blinded studies has detected more than a 10-fold separation between Alzheimer’s patients and age-matched normal healthy controls or young cognitive intact subjects.

Financials on September 30, 2019:

– Cash Cash Equivalents: $17.8 million
– Debt: None

SAVA has traded in a range of $0.22 to $5.50 in the last 1 year. The stock touched an intraday high of $5.50 on Friday (Dec.27), before closing at $5.29, up 29.28%.

Alfa Laval Wins SEK 95 Million Waste Heat Recovery Order

LUND, Sweden, Dec. 30, 2019 /PRNewswire/ — Alfa Laval – a world leader in heat transfer, centrifugal separation and fluid handling – has won an order to supply waste heat recovery systems to a power plant in El Salvador. The order has a value of approximately SEK 95 million and is booked in the Boiler Systems unit of the Marine Division. Deliveries are scheduled for 2020.

The order comprises exhaust gas heat recovery boilers to be installed in an engine power plant where they will recover waste heat to be used in the electricity generation process.   

“Our reliable and efficient boiler systems re-use waste heat and makes it possible to produce additional electricity from the same energy source. This has a positive impact on our customers bottom line – and it is good for the environment,” says Sameer Kalra, President of the Marine Division.

Did you know that - these boilers are able to recover nearly 115 MW otherwise wasted thermal energy – and when turned into electricity it will meet the annual electricity consumption of 200 000 people in El Salvador?

About Alfa Laval                                                                                                                 

Alfa Laval is a leading global provider of specialized products and engineering solutions based on its key technologies of heat transfer, separation and fluid handling.

The company’s equipment, systems and services are dedicated to assisting customers in optimizing the performance of their processes. The solutions help them to heat, cool, separate and transport products in industries that produce food and beverages, chemicals and petrochemicals, pharmaceuticals, starch, sugar and ethanol.

Alfa Laval’s products are also used in power plants, aboard ships, oil and gas exploration, in the mechanical engineering industry, in the mining industry and for wastewater treatment, as well as for comfort climate and refrigeration applications.

Alfa Laval’s worldwide organization works closely with customers in nearly 100 countries to help them stay ahead in the global arena. Alfa Laval is listed on Nasdaq OMX, and, in 2018, posted annual sales of about SEK 40.7 billion (approx. 4.0 billion Euros). The company has about 17 200 employees.

www.alfalaval.com

For more information please contact:
Peter Torstensson
Senior Vice President, Communications
Alfa Laval
Tel: + 46-46-36-72-31
Mobile: +46-09-33-72-31

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SOURCE Alfa Laval

KPMG’s Asia Pacific region sees strong FY19 revenue growth as regional strategy takes off

HONG KONG, Dec. 30, 2019 /PRNewswire/ – KPMG’s Asia Pacific region has seen a regional revenue increase of 9.3% for FY19 delivered on the back of an ambitious strategy announced a year ago. This continues the strong growth streak posted by the region in recent years as its investments in people, innovation and technology start to take off.

Honson To, Chairman of KPMG’s Asia Pacific region and Chairman of KPMG China said: “I’m particularly delighted that Asia Pacific continues to be the fastest growing region at KPMG, driven by a 14.1% growth in services provided by Advisory.”

All three key functions saw clear growth, with revenues of US$2.14 billion in Audit, US$0.87 billion in Tax Legal, US$2.13 billion in Advisory, and US$5.14 billion overall in Asia Pacific.  

As part of its trust and growth strategy, KPMG’s Asia Pacific region announced last year an ambition to double in size by 2023.The region has committed to a multi-year investment program which will further develop holistic and tailored solutions for its clients, and support co-creation with clients and alliances through innovation hubs, ignition centres and other centres of excellence across the region.

An example of this is the KPMG Origins tracker which empowers supply chain participants across multiple industries with a blockchain-based track and trace solution. Additional solutions focused on cyber security challenges work by patrolling and monitoring systems, allowing for identification of suspicious activities happening under the radar.

And investments in cybersecurity, blockchain, cloud-based and technology tools and solutions, and KPMG’s Audit technology platform, KPMG Clara, are already aiding clients in new unimagined ways.

“Our clients are reacting positively to the services and solutions which are helping them to transform. The trajectory continues to look healthy for KPMG in Asia Pacific as we grow stronger together, and as the organization looks to this region to act as a global growth engine,” added To.

“Ways of working are evolving, expectations are changing, geopolitics are impacting trading performance and technology is racing ahead, sometimes even before the last new thing has been fully explored.”

“To this end, KPMG’s investments in people remain unabated so we can continue to make a difference for our clients. And while we have grown to more than 46,000 people in Asia Pacific, we continue our plans to create more professional roles focused on broadening our capability to include STEM skills and developing the next generation of cyber security, cloud and regulatory change experts, solution architects and digital transformation specialists. This is in line with KPMG’s investment of $5 billion globally in innovation, people and technology over the next five years to create value for our people and clients.”

Audit, Tax and Advisory

Audit

KPMG is committed to improving quality and consistency by investing in game-changing methodologies and technology innovations. During 2019 KPMG continued the roll out of KPMG Clara, our smart audit platform which brings KPMG’s powerful data and analytics capabilities into one interface, allowing our professionals to work smarter while interacting with clients online in real time as they conduct the audit.

As part of the network’s collective strategy all KPMG firms are committed to driving tangible and sustainable advances in quality and consistency. As a global organization, KPMG is driving the use of centralization to achieve the consistency regulators and stakeholders expect and deserve.

Tax Legal Services*

Growth in Legal Services has been supported by the continuing expansion of coverage of the offering across KPMG in the region.

With the introduction of new technologies and enhanced service offerings, KPMG has been able to help tax and legal leaders not only meet compliance obligations but also transform their departments and establish new ways of working through such initiatives as Tax Reimagined, KPMG’s unique framework that combines the strengths of our technology, transformation and compliance capabilities. KPMG’s work in the region has been recognised with industry awards including the International Tax Review’s 2019 award for Asia’s Transfer Pricing and Disputes and Litigation Firm of the Year.

Advisory

As our clients shape, transform and protect their businesses to maintain a competitive edge in an increasingly digital world, they are looking to KPMG’s capabilities and globally-minded practitioners to help them address these critical challenges and opportunities. KPMG’s deep industry expertise, a future-focused view of sectors and business models and our strong tools, methods and technologies help clients hone their strategies, align their operations across the enterprise, and become more customer centric.

KPMG is proud to be recognised as the top consulting organization in Asia Pacific in 2018 by Source Consulting.  In 2019, KPMG was ranked as a Leader in 25 major evaluations in areas central to our client’s transformation agendas including cybersecurity and artificial intelligence, digital change management, and corporate services as well as our Powered Enterprise and Connected Enterprise solutions.

KPMG FY19 member firm revenues (US$ billions)

 

All figures throughout this document are in US dollars. All growth figures are in local currency except where noted.

FY19 and FY18 revenues, reported in USD billions, are translated at the average exchange rates prevailing in each respective financial year.

The industry analysis excludes revenues reported outside of KPMG’s standard sector taxonomy. Prior year figures have been restated to reflect FY18 sector reclassifications.

Local growth percentages are based on maintaining consistent FY19 exchange rates across both FY19 and FY18.

The following global reports have also been issued by KPMG International:

KPMG’s 2019 Global Review reflects on our record of achievement over the past year, demonstrating the insights and expertise of KPMG professionals and the unrelenting focus on acting with integrity and quality in everything we do.

KPMG’s 2019 International Transparency Report provides insights and details on how we continually strive to enhance audit quality, which is a direct reflection of the KPMG network’s unwavering commitment to audit quality, an integral element of our business and culture.

About KPMG

KPMG is a global network of professional services firms providing Audit, Tax and Advisory services. We operate in 147 countries and territories and have more than 219,000 people working in member firms around the world. In Asia Pacific, KPMG operates in 20 countries and territories with more than 46,000 people in members firms in the region. The independent member firms of the KPMG network are affiliated with KPMG International Cooperative (“KPMG International”), a Swiss entity. Each KPMG firm is a legally distinct and separate entity and describes itself as such.

The financial information set forth represents combined information of the separate KPMG member firms that perform professional services for clients. The information is combined here solely for presentation purposes.  KPMG International performs no services for clients nor, concomitantly, generates any client revenue.

Headcount figures are expressed as FTE (full-time equivalent) and are based on average headcount for the financial year.

Disclaimer

Throughout this document, “we”, “KPMG”, “us” and “our” refer to the network of independent member firms operating under the KPMG name and affiliated with KPMG International or to one or more of these firms or to KPMG International. KPMG International provides no client services. No member firm has any authority to obligate or bind KPMG International or any other member firm vis-a-vis third parties, nor does KPMG International have any such authority to obligate or bind any member firm.

Throughout this document, references to “Firm”, “KPMG firm”, “member firm” and “KPMG member firm” refer to firms which are either: members of KPMG International as a matter of Swiss law; sublicensee firms of KPMG International; or entities that are owned, managed and controlled by an entity that is a member or a sublicensee. The overall governance structure of KPMG International is provided in the ‘Governance and leadership’ section of the KPMG International Transparency
Report.

 

SOURCE KPMG China

2019 Top 10 Celebrity Homes: Jennifer Aniston, Alicia Keys, Kelly Clarkson, Kaley Cuoco & More

POMPANO BEACH, Fla., Dec. 30, 2019 /PRNewswire-PRWeb/ — “2019 Top 10 Celebrity Homes”

With the new year here, TopTenRealEstateDeals.com has rounded up our most popular celebrity homes of 2019. The homes run the gamut from mid-century modern to tropical-island style with many beside lakes or ocean. Some of the homes were owned by stars who were just starting their rise to celebrity status and others were purchased after reaching their pinnacle of success. They vary widely in size and style, each giving us insight to the taste of the owner.

1) “Girl on Fire” and 15-time-Grammy-winner, Alicia Keys bought the Razor House in 2019 for $20.8 million. The home’s sleek contemporary lines and commanding views over the Pacific Ocean have graced the pages of cutting-edge magazines and websites around the world, in addition to a starring role in Visa Black Card and Calvin Klein television commercials. Designed by Wallace E. Cunningham in La Jolla, California, it was on the market originally at $45 million, then at $30 million, reduced to $24.995 million, with Keys paying $20.8 million.

2) The former home of Brad Pitt and Jennifer Aniston was going to be their forever love nest when they bought it in 2001 soon after their much publicized Malibu marriage. After extensive updating and adding a tennis court and guest house, their separation was announced and the home sold in 2006 to a hedge fund executive who completed the renovation and added some features of his own. Once again on the market, it is priced at $44.5 million.

3) Kelly Clarkson made a meteoric rise to stardom after singing and winning the first season of ‘American Idol’ in 2002. Kelly is now one of America’s favorite entertainers, judge on ‘The Voice’ and host of her new NBC talk show. Ten years after her ‘American Idol’ win, Kelly bought a Tennessee lake home in Hendersonville, 25 miles up the Cumberland River from Nashville that is for sale priced at $7.49 million.

4) Since ‘The Big Bang Theory’ came to a close in May, Kaley Cuoco and her husband, equestrian Karl Cook, are busy building their dream home, so she put her Tarzana-neighborhood home in Los Angeles on the market at $4.895 million. Cuoco bought the house from Lamar Odom and Khloe Kardashian in 2014. With the house decorated in Kaley’s exciting contemporary style, it was rapidly sold.

5) Cheryl Tiegs was America’s favorite model in the 1970s and ’80s as the three-time cover girl for ‘Sports Illustrated’ swimsuit issues, four-time covers on ‘People’ and three times at ‘Time.’ Her ’70′s posters in a white fishnet bathing suit and then her pink bikini photo solidified her role as America’s first baby-boomer supermodel. Almost as beautiful as Cheryl, her Balinese-style Bel Air home is for sale at $18.5 million.

6) Oprah owns at least six homes currently after selling her Chicago and Atlanta homes. Lately, her focus has been on the Montecito neighborhood of Santa Barbara. She purchased actor Jeff Bridges’ home after waiting for the price to be reduced from the original $7.495 million and ended up buying it for $6.85 million – the exact price Bridges and his wife, Susan Geston, paid for it five years ago.

7) Joe Pesci will always be known for his roles as Vinny Gambini, Joe Pesci’s character in the Deep South legal comedy ‘My Cousin Vinny,’ or Nicholas “Nicky” Santoro, his mob character with animal killer instincts in ‘Casino’ and now with a new Netflix film ‘The Irishman.’ Having made the decision to move to the perpetual sunshine and warmth of California, he has put his New Jersey waterfront mansion on the market that is priced at $6.5 million.

8) Suzanne Somers has an instinct for romance whether the proof is evident in her long, successful marriage to husband Alan Hamel, or the romantic home environments she creates. Their home in the hills above Palm Springs is the perfect example of the ultimate hideaway they’ve enjoyed for years and are now selling for the price of $9.5 million.

9) Adam Lambert’s style has propelled him from an ‘American Idol’ superstar singer-songwriter into an international celebrity. The house he bought in 2009 that overlooks the Sunset Strip, the same year he appeared on ‘American Idol,’ reflects his personality along with his penchant for drama. Now traveling the world almost full-time performing in tours and major guest appearances, the Grammy-nominated vocalist has recently put his West Hollywood Hills home on the market for $3.35 million.

10) Since she became Duchess of Sussex and a princess of the United Kingdom, those fascinated by British royalty can’t get enough of all things Megan Markle. That includes the house she lived in when she was married to Trevor Engelson. They rented a charming Colonial-style home in L.A.’s Hancock Park neighborhood – a stone’s throw from downtown Hollywood. It is now for sale, priced at $1.75 million.

Visit TopTenRealEstateDeals.com for a tour of 2019′s Top 10 Celebrity Homes and for more spectacular homes and real estate news.

 

SOURCE TopTenRealEstateDeals.com

The Dash Gold Foundation promotes BDSG digital currency era based on gold (SKR)

SEOUL, South Korea, Dec. 30, 2019 /PRNewswire/ — The Dash Gold Foundation announced that it will use the gold SKR (Safe Keeping Receipt) to promote BDSG digital currency payment business, online shopping mall and gold sales business, and digital currency ATM business.

Gold Safe Keeping Receipt (SKR) is a SKR (Gold 100 Metric Tons, New Assay Report BSP Mint / Refinery 99.8% / 99.9%) issued by BankoSentralng Pilipinas, and the beneficiary is the Dash Gold Foundation. BDSG, a digital currency based on gold SKR has attracted great attention in that it can have value and be used as a payment method in real life through the progress of bank guarantees.

The BDSG online shopping mall connects BDSG (Beyond Dashgold) digital currency with gold-based utilizing gold SKR (Safe Keeping Receipt) along with USDT, a stable coin that maintains a certain value. It will serve about 25 million members of Bit-z and Bit-z federation exchanges, and BDSG will be used as a major payment method in online shopping malls selling mainly luxury goods, cosmetics, gold, etc.

When the BDSG online shopping mall is opened, it is expected that there will be a groundbreaking opportunity to use digital currency as a payment method for physical transactions. BDSG will soon be listed on the Bitgetexchange. It is expected to increase its value by increasing users’ utilization with wider purchases.

On the other hand, the Dash Gold Foundation is developing a block chain ATM business that can operate over 30 digital currencies based on SKR as a joint project with financial banks based on the gold SKR that can be used in real life, BDSG digital currency will be installed and operated in BDSG online shopping malls and cryptocurrency ATMs. The value of BDSG is expected to increase in the future.

 

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SOURCE The Dash Gold Foundation